{"id":11668,"date":"2020-12-08T14:13:38","date_gmt":"2020-12-08T19:13:38","guid":{"rendered":"https:\/\/www.cbtdbtassociates.com\/cbtdbtassociates.com\/?p=11668"},"modified":"2024-03-04T14:33:23","modified_gmt":"2024-03-04T14:33:23","slug":"cbt-corrects-brain-abnormality-in-patients-with-ocd","status":"publish","type":"post","link":"https:\/\/www.cbtdbtassociates.com\/cbt-corrects-brain-abnormality-in-patients-with-ocd\/","title":{"rendered":"CBT Corrects Brain Abnormality in Patients with OCD"},"content":{"rendered":"\r\n

“Researchers have discovered a brain abnormality in people with obsessive-compulsive disorder<\/a><\/strong> (OCD) that may help predict which patients are most likely to respond to treatment with cognitive behavioral therapy<\/a><\/strong> (CBT), according to a study published online in\u00a0Brain Imaging and Behavior.<\/em><\/p>\r\n\r\n\r\n\r\n

\u201cThe hemodynamic response function (HRF) represents the transfer function linking neural activity with the functional MRI (fMRI) signal, modeling neurovascular coupling,\u201d wrote Jamie Feusner, MD, professor-in-residence of psychiatry and biobehavioral sciences at University of California – Los Angeles Health Sciences, and coauthors. \u201cSince HRF is influenced by non-neural factors, to date it has largely been considered as a confound or has been ignored in many analyses.\u201d<\/p>\r\n\r\n\r\n\r\n

For the study, researchers used fMRI scans to estimate the HRF in 44 adults with OCD and found abnormalities in brain regions including the caudate. After 4 weeks of CBT, however, the abnormalities appeared to normalize. The pattern was not reflected in 25 healthy control subjects who also underwent fMRI scans 4 weeks apart.<\/p>\r\n\r\n\r\n\r\n

Furthermore, pretreatment HRF patterns in the caudate were able to predict a patient\u2019s response to CBT with 86.4% accuracy, researchers reported.<\/p>\r\n\r\n\r\n\r\n

If confirmed in future studies, the findings could help clinicians better decide which patients should receive CBT as a first-line treatment for OCD<\/a><\/strong>. Additionally, abnormalities in neurovascular coupling, or how neural activity is linked to blood flow, could represent a new treatment target.”<\/p>\r\n\r\n\r\n\r\n

If you are struggling with OCD and are interested in learning more about CBT<\/a> and our new OCD group, click here.<\/a><\/p>\r\n\r\n\r\n\r\n

Click here<\/a> for the full article by Jolynn Tumolo<\/p>\r\n\r\n\r\n\r\n

References<\/strong><\/p>\r\n\r\n\r\n\r\n

Rangaprakash D, Tadayonnejad R, Deshpande G, O’Neill J, Feusner JD. FMRI hemodynamic response function (HRF) as a novel marker of brain function: applications for understanding obsessive-compulsive disorder pathology and treatment response.\u00a0Brain Imaging and Behavior.<\/em>\u00a02020 August 6;[Epub ahead of print].<\/a><\/p>\r\n\r\n\r\n\r\n

Cognitive behavioral therapy normalizes brain abnormality in OCD patients [press release]. Los Angeles, California:\u00a0University of California – Los Angeles Health Sciences; October 14, 2020.<\/a><\/p>\r\n","protected":false},"excerpt":{"rendered":"

Researchers have discovered a brain abnormality in people with obsessive-compulsive disorder (OCD) that may help predict which patients are most likely to respond to treatment with cognitive behavioral therapy (CBT), according to a study published online in\u00a0Brain Imaging and Behavior.<\/p>\n

\u201cThe hemodynamic response function (HRF) represents the transfer function linking neural activity with the functional MRI (fMRI) signal, modeling neurovascular coupling,\u201d wrote Jamie Feusner, MD, professor-in-residence of psychiatry and biobehavioral sciences at University of California – Los Angeles Health Sciences, and coauthors. \u201cSince HRF is influenced by non-neural factors, to date it has largely been considered as a confound or has been ignored in many analyses.<\/p>\n","protected":false},"author":3,"featured_media":11669,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[24],"tags":[],"acf":[],"yoast_head":"\nCBT Corrects Brain Abnormality in Patients with OCD<\/title>\n<meta name=\"description\" content=\"Researchers have discovered a brain abnormality in people with OCD that may help predict which patients are most likely to respond to treatment with CBT.\" 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